Welcome to Stem Cell and Leukaemia Proteomics Lab

The Stem Cell And Leukaemia Proteomics Lab (SCALPL) was formed from a cellular development group in the late 1990's to exploit proteomics to further our understanding of Leukaemia and Stell Cell Biology. Applying cutting edge proteomic techniques we developed we are now are we able to extend the knowledge base obtained from gene array studies to gain an insight into the intricacies of signal transduction and how aberrant post translational modifications control stem cell biology and leukaemogenesis.

We are an exceptionally well equipped Proteomics lab with nanoflow liquid chromatography and access to electrospray Time-of-Flight and MALDI ToF-ToF tandem mass spectrometers, hybrid Triple Quadrupole/ion trap mass spectrometers and Orbitrap ion mass spectrometers.

The aim of our programme is to identify key common events which contribute to the molecular pathogenesis of myeloproliferative disorders and myeloid leukaemias thereby developing new understanding of transformation processes and how they may be disrupted.

The rapidly developing Proteomics technology now yield extremely complex data sets. New Bioinformatic solutions are required to handle large and heterogeneous data sets to improve the knowledge discovery process.

Stem cells offer tremendous potential to develop treatments for numerous diseases. Using Proteomics we are attempting to further our understanding of the basic cellular process underlying stem cell self-renewal, maintenance and differentiation.